Tomo Kishimura

Qualification

Patent Attorney (Japan)
Ph.D. (Science)

Practice Areas

Patent
Electrical Engineering, Electronics, Software/ Biotechnology

Education

Doctor of Science, School of Life Science and Technology, Tokyo Institute of Technology
Master of Science, The Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Bachelor of Science, Dept. of Life Science and Technology, Tokyo Institute of Technology

Work Experience

Dr. Kishimura received his Doctor of Science degree at Tokyo Institute of Technology in 2021. He was engaged in developing a chemical-modified nucleic acid for nucleic acid medicine. He joined RYUKA & PARTNERS in 2021.

Research Content
(1) Dr. Kishimura proactively studied molecular biology (metabolism, photosynthesis, DNA replication, transcriptional regulation, translational regulation, etc.), organic chemistry, and information biology, etc. at the Department of Bioscience and Biotechnology at the Tokyo Institute of Technology. He skipped a grade and graduated at the top of his department, receiving the Takamiya Award for academic excellence.

(2) Under the guidance of Associate Professor Kohji Seio at the Tokyo Institute of Technology, School of Life Science and Technology, Department of Life Science and Technology, he researched the synthesis of artificial nucleic acids with sugar modifications at the 5' end of nucleic acids, aiming to improve the intracellular reachability of nucleic acid.

(3) Dr. Kishimura also studied the synthesis method of chemical modifications to the 2' hydroxyl group of nucleic acid and the thermodynamic and biological properties of the modified nucleic acids. He established an efficient synthetic route to introduce an alkyl-carbamoylethyl group into the 2' hydroxyl group of nucleic acid, and found that introducing an alkyl group via an ethyl carbamoyl group into the 2' hydroxyl group of a nucleic acid enables fine-tuning its biological properties and liposolubility without affecting its thermodynamic properties [1].

[1] Kishimura T, Tomori T, Masaki Y, Seio K, "Synthesis of 2′-O-alkylcarbamoylethyl-modified oligonucleotides with enhanced nuclease resistance that form isostable duplexes with complementary RNA" Bioorg. Med. Chem. Lett. 2021 Mar 1;35:127779. doi: 10.1016/j.bmcl.2021. 127779).

Membership

Japan Patent Attorneys Association (JPAA)